1178-1183 Gong LAJP 3235:Gong
نویسندگان
چکیده
Deacetylation degree (DD) is one of the most important characteristics of chitosan and has great impact on its physicochemical and biological properties. In this study, three kinds of chitosan with different DD were prepared. By means of living imaging technique and fluorescent quantitative technique, the influences of different DD on the distribution of chitosan in vivo were investigated. The results showed that chitosan with molecular weight between 20,000 and 26,000 mainly distributed in kidney after intravenous injection. The influences of DD on the distribution of chitosan in kidney was obvious. The renal distribution of chitosan with 38, 51, and 61% DD achieved the maximum concentration in 60, 30, and 60 min, respectively. The concentration of chitosan with 51% DD was much higher than that of chitosan with 38% and 61% DD, which suggested that the chitosan with 51% DD might obtain better kidney targeting capacities and be considered as a better kidney targeting drug delivery carrier.
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